ABSTRACT
The research community responded rapidly to the SARS-CoV-2 pandemic with a burst of proteomic studies to understand this new virus. We focus in this chapter on proteomic approaches and advances in the areas of the viral proteome and the viral-host protein-protein interactions exploited to facilitate the pathogenic life cycle of SARS-CoV2. We also outline the proteome and posttranslational protein modifications of infected cells and blood proteomics of COVID-19 patients in relation to pathogenesis, host response, and disease severity. Finally, tools and application for COVID-19 proteomics and implementations in diagnostics and therapies are surveyed before summarizing the present achievements and future perspectives. © 2023 Elsevier Inc. All rights reserved.
ABSTRACT
Purpose This exploratory research aims to (1) investigate the bright and dark sides of social media use during the COVID-19 pandemic;(2) explore the impact of demographic factors on social media usage;and (3) assess the effects of cultural dimensions on social media usage. Design/methodology/approach The data are collected through an online survey. Factors derived from grounded theories and models such as affordance theory and Hofstede's cultural framework were considered. Spearman correlation and nonparametric analysis were used to test the hypotheses. Findings The results revealed that social media usage was positively associated with healing and affiliation, and negatively associated with self-control. There are also positive associations between social media usage and sharing information related to COVID-19 without verification, perceived reliability of COVID-19 information on social media and relapse. The impact of demographic and cultural factors indicated significant effects of gender, age, marital status, educational level, power distance and collectivism on social media usage, sharing information, perceived information reliability, healing and affiliation. Originality/value This study contributes to technology affordances by examining social media's positive and negative affordances in a new context (COVID-19 pandemic). From the positive side, this study explores the use of social media for healing and affiliation. As for the negative impact of social media during the pandemic, this study assesses the user's addiction to social media use (relapse) and perception of the social media information reliability and information sharing without verification. It is among few research endeavors conducted in a non-Western country. This study also examines the influence of demographic and cultural factors on social media users. The results provide insights for both researchers and policymakers regarding social media usage.